Jiangsu Vcare's Oral Treatment VC005 for Atopic Dermatitis enters Phase III Clinical Study
Published Time:
2024-10-22 17:33
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VC005 tablets, developed by Jiangsu Vcare Pharmatech Co., Ltd. (Jiangsu Vcare), is a new-generation highly selective JAK1 inhibitor. The oral treatment of moderate-to-severe atopic dermatitis has initiated a Phase III clinical trial. It is a multicenter, randomized, double-blind, placebo parallel-controlled Phase III clinical study, aiming to evaluate the efficacy and safety of VC005 tablets for adult patients with moderate-to-severe atopic dermatitis. The trial is led by the Institute of Dermatology, Chinese Academy of Medical Sciences.
Positive top-line data has been obtained from the unblinded Phase II clinical study, showing key indicators, that are superior to the best drugs of the same class. Meanwhile, the overall safety and tolerability of the drug are good. In particular, adverse reactions related to the blood system in the high-dose group are milder than those of other drugs the same class, and no bone marrow suppression effect is observed.
In addition, VC005 is also being developed as a topical gel for patients with mild-to-moderate atopic dermatitis. The Phase II clinical trial is about to be initiated, and the project plans to expand its indications for atopic dermatitis in the future.
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