Use advanced computer-aided drug design technology to promote new drug research and development. Specific applications of CADD include compound structure-activity relationship (SAR) analysis, structure-based drug design (SBDD), high-throughput virtual screening (HTVS) and other technologies, as well as quantitative structure-activity relationship (QSAR) and quantitative structure-property relationship (QSPR), quantitative structural toxic relationship (QSTR) and other theoretical foundations to predict the properties of ADME/T.
Candidate compounds' drug ability evaluation, preclinical pharmacodynamics, pharmacokinetics research and toxicity prediction
Continuous Flow Technology
The continuous flow technology can optimize the size and performance of the reactor according to the specific reaction process and goals, and has the characteristics of safety, high efficiency, high quality and low cost. Continuous flow technology can improve process safety, provide new synthetic routes, improve reaction selectivity, and reduce downstream processing costs. In the research and development stage, the technology can meet the needs of basic reaction debugging on a small scale. In the production implementation stage, the technology can meet the large-scale industrial production.
Enzyme Catalysis Technology
Enzyme catalysis technology produces many finished drugs and pharmaceutical intermediates through the production of primary metabolites, intermediate metabolites, secondary metabolites, and catalytic conversion and resolution. It is especially widely used in the production of chiral drugs and intermediates.
Crystal Form Research
Crystal form research screens candidate compounds for crystal and salt types, comprehensively characterize of dominant crystal types, and develop crystallization technology. It is of great help to improving the drug-making properties of active substances, as well as patent protection and breakthroughs.
Separation Preparation Technology
Vcare has a variety of modes of preparative chromatography separation technology. The preparative liquid system is equipped with a complete range of preparative chromatography columns for normal phase chromatography, reverse phase chromatography, ion exchange chromatography, HILIC chromatography, and chiral separation related fillers.
Chiral Drug Analysis Techniques
Commonly used chiral drug analysis techniques include high-performance liquid chromatography, capillary electrophoresis, molecular imprinting technology, high-speed countercurrent chromatography, supercritical fluid chromatography, and biological enzymatic methods.
Chiral Drug Synthesis Techniques
Chiral pharmaceutical chemical preparation methods include chromatographic resolution, chemical resolution, induced crystallization resolution, membrane separation technology and other drug enantiomer resolution, chiral source synthesis method, chiral catalysis method. The biological preparation methods of chiral drugs mainly include enzymatic resolution of chiral drugs and enzymatic synthesis of chiral drugs.
High-end complex formulations have high technical barriers. Liposomes, intravenous emulsions, microspheres, suspension injections, oil solutions, micelles and other high-end complex preparations have obvious clinical advantages. They have better effectiveness and safety, are more suitable for the treatment of target diseases, are convenient for doctors to operate, simplify dosing regimens, improve patient compliance, and can meet unmet clinical needs.